Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain
Summary: Omicron, as the emerging variant with enhanced vaccine tolerance, has sharply disrupted most therapeutic antibodies.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the subgenus sal manaro knives Sarbecovirus, members of which share high sequence similarity.Herein, we report one sarbecovirus antibody, 5817, which has